P-Selectin/CD62P Products

Description

CD62P is a member of the small selectin family of cellular adhesion molecules, which also includes CD62E and CD62L. Its structure, similar to the other members of the selectin family, consists of an N terminal lectin like domain of C type, followed by an epidermal growth factor like motif, a series of short consensus repeats, a transmembrane domain, and a cytoplasmic tail. The CD62P antigen is a 140 kDa glycoprotein, located in the alpha granules and the dense granules of platelets and endothelial cells. Activation of these cells results in rapid mobilization of CD62P from the storage granules to the cell surface. Activated platelets have a stable CD62P expression, while the endothelial cells lose CD62P expression within 1 h of activation, because of endocytosis of the molecule. CD62P is also expressed on megakaryocytes, but resting platelets and endothelial cells show no surface staining of CD62P.

Bioinformatics

Entrez	20344 Mouse 25651 Rat 6403 Human
Uniprot	AAH68533 Human AAH68533.1 Human NM_003005 Human P16109 Human Q01102 Mouse
Product By Gene ID	6403
Alternate Names	CD62P antigen FLJ45155 PADGEMantigen CD62) selectin P (granule membrane protein 140kDa, antigen CD62)