Species: Hu, Mu, Rt, Gp
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Gp, Ca
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Rt
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: WB, ELISA, MA, AP
Description
The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that share a c-terminal sequence and have an established role in neurotransmission. The mammalian tachykinins include substance P (NK1), neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Human
Human
Rat
Human
|
| Product By Gene ID |
6869 |
| Alternate Names |
- NK-1R
- NK1Rneurokinin 1 receptor
- NKIR
- SPRsubstance-P receptor
- TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)
- tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
- tachykinin receptor 1NK-1 receptor
|
