MLH3 Products

Description

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Bioinformatics

Entrez	27030 Human
Uniprot	NP_001035197.1 Human NP_055196 Human Q2M1Z1 Human Q9UHC1 Human
Product By Gene ID	27030
Alternate Names	DNA mismatch repair protein Mlh3 HNPCC7 MGC138372 mutL (E. coli) homolog 3 mutL homolog 3 (E. coli) MutL protein homolog 3

Research Areas for MLH3

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
Mismatch Repair