MEKK1 Products

Description

MEKKs (Mitogen activated protein kinase kinase kinases) are serine-threonine kinases that act as the first tier of cellular MAP kinase pathways by activation of MAP/ERK kinases, or MEKs. Many enzymes with MEKK activity have been identified, including MEKK1-4, Raf, MLK3, TAK, and DLK. MEKKs generally display little similarity outside of their catalytic kinase domains. MEKK1-4 are nearly 50% identical within their catalytic domains, and are known to regulate Erk, Jnk, and p38 MAP kinase pathways. MEKK2 and MEKK3 bind MEK5 via conserved PB1 domains, leading to downstream activation of Erk5.

Bioinformatics

Entrez	116667 Rat 4214 Human
Uniprot	NP_005912 Human Q13233 Human
Product By Gene ID	4214
Alternate Names	Map3k1 MAPK/ERK kinase kinase 1 MAPKKK1MAP/ERK kinase kinase 1 MEK kinase 1 MEKK1EC 2.7.11.25 MEKKMEKK 1 mitogen-activated protein kinase kinase kinase 1

Research Areas for MEKK1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Breast Cancer
Cancer
Lipid and Metabolism
MAP Kinase Signaling
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases