ITK Products

Description

Emtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells (1). Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains (2). It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs (3). Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28 (4).

Bioinformatics

Entrez	16428 Mouse 3702 Human
Uniprot	AAI09078.1 Human ITK_HUMAN Human NM_005546 Human NP_005537 Human Q08881 Human
Product By Gene ID	3702
Alternate Names	EC 2.7.10 EC 2.7.10.2 EMTMGC126257 homolog of mouse T-cell itk/tsk IL2-inducible T-cell kinase Kinase EMT LYKMGC126258 PSCTK2 T-cell-specific kinase tyrosine-protein kinase ITK/TSK Tyrosine-protein kinase Lyk

Research Areas for ITK

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Protein Kinase