Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt, Po, Bv, Ca
Applications: WB, ELISA, IHC
Host: Goat Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The growth factor bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain and two SH3 domains (1). GRB2 associates with Tyrosine phosphorylated EGFRs and PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin receptor to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adaptor protein, recruits Sos for Ras activation and subsequent signal transmission (3).
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
2885 |
| Alternate Names |
- abundant SRC homology
- Adapter protein GRB2
- ASH
- EGFRBP-GRB2
- epidermal growth factor receptor-binding protein GRB2
- Grb3-3
- growth factor receptor-bound protein 2
- growth factor receptor-bound protein 3
- HT027
- MST084
- MSTP084
- NCKAP2
- Protein Ash
- SH2/SH3 adapter GRB2
|
![Immunohistochemistry GRB2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/GRB2_AF3846_Immunohistochemistry_6809.jpg)
![Western Blot GRB2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/GRB2_AF3846_Western_Blot_5355.jpg)
