Fc epsilon RI Products

Description

The allergic reaction is mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FceRI receptor is a tetrameric complex, consisting of a a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

Bioinformatics

Entrez	14125 Mouse 2205 Human
Uniprot	AAH05912 Human AAH05912.1 Human NM_002001 Human NP_001992.1 Human P12319 Human P20489 Mouse
Product By Gene ID	2205
Alternate Names	alpha polypeptide Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Fc-epsilon RI-alpha FcERI high affinity immunoglobulin epsilon receptor alpha-subunit high affinity immunoglobulin epsilon receptor subunit alpha high-affinity, of mast cells, alpha polypeptide

Research Areas for Fc epsilon RI

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Asthma
Cancer
Immunology
Signal Transduction