CYP24A1 Products

Description

The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is involved in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.

Bioinformatics

Entrez	1591 Human
Uniprot	NP_000773 Human NP_000773.2 Human Q07973 Human
Product By Gene ID	1591
Alternate Names	25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CP241 CYP241,25-alphadihydroxyvitamin D3 24-hydroxylase Cytochrome P450 24A1 cytochrome P450, family 24, subfamily A, polypeptide 1,24-OHase cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) Cytochrome P450-CC24 EC 1.14.13.n4 exo-mitochondrial protein MGC126273 MGC126274 P450-CC24 vitamin D 24-hydroxylase Vitamin D(3) 24-hydroxylase