BPTF/FALZ Products

Description

FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex.

Bioinformatics

Entrez	2186 Human
Uniprot	Q12830 Human
Product By Gene ID	2186
Alternate Names	bromodomain and PHD domain transcription factor Bromodomain and PHD finger-containing transcription factor bromodomain PHD finger transcription factor EC 3.6.1 EC 6.2.1.5 FAC1fetal Alz-50 reactive clone 1 FALZnucleosome-remodeling factor subunit BPTF Fetal Alz-50 clone 1 protein Fetal Alzheimer antigennucleosome remodeling factor, large subunit NURF301