BMPR-II Products

Description

BMPR2 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq]

Bioinformatics

Entrez	659 Human
Uniprot	NM_001204 Human NP_001195 Human NP_001195.2 Human Q13873 Human
Product By Gene ID	659
Alternate Names	BMP type II receptor BMP type-2 receptor BMPR-2 BMPR3 BMPR-IIprimary pulmonary hypertension 1 Bone morphogenetic protein receptor type II bone morphogenetic protein receptor type-2 bone morphogenetic protein receptor, type II (serine/threonine kinase) BRK-3 EC 2.7.11 EC 2.7.11.30 FLJ41585 FLJ76945 PPH1BMR2 T-ALK type II activin receptor-like kinase type II receptor for bone morphogenetic protein-4

Research Areas for BMPR-II

Find related products by research area and learn more about each of the different research areas below.

Mesenchymal Stem Cell Markers
Protein Kinase
Stem Cell Markers