Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Ca
Applications: ELISA, Flow, ICC/IF
Host: Goat Polyclonal
Species: Hu
Applications: Flow, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AP
Description
This study investigates the involvement of alpha2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal alpha2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, alpha1D-AR, were not changed by the treatment. Moreover, alphao-subunits of GTP-binding proteins (Galphao), one of the downstream molecules of alpha2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of alpha2A-AR in the mouse hippocampus.
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
150 |
| Alternate Names |
- ADRA2
- ADRA2Ralpha-2-adrenergic receptor, platelet type
- ADRARZNF32
- adrenergic, alpha-2A-, receptor
- Alpha-2 adrenergic receptor subtype C10
- alpha-2A adrenergic receptor
- Alpha-2A adrenoceptor
- Alpha-2A adrenoreceptor
- alpha-2AAR subtype C10
- ALPHA2AAR
- Alpha-2AAR
|
Research Areas for alpha-2A Adrenergic R/ADRA2A
Find related products by research area and learn more about each of the different research areas below.
GPCR
![Flow Cytometry alpha-2A Adrenergic R/ADRA2A Antibody (1006614) [Unconjugated]](http://images.novusbio.com/fullsize2/alpha2A_Adrenergic_R_MAB10129_Flow_Cytometry_23250.jpg)
