Aldo-keto Reductase 1C3/AKR1C3 Products

Description

AKR1C3 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Bioinformatics

Entrez	8644 Human
Uniprot	AAH01479 Human AAH01479.1 Human NP_003730 Human NP_003730.4 Human P42330 Human
Product By Gene ID	8644
Alternate Names	17-beta-hydroxysteroid dehydrogenase type 5 3-alpha-HSD type 2 3-alpha-hydroxysteroid dehydrogenase type 2 aldo-keto reductase family 1 member C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) Chlordecone reductase homolog HAKRb DD-3 DD317-beta-HSD 5 DDH1 DDX Dihydrodiol dehydrogenase 3 Dihydrodiol dehydrogenase type I dihydrodiol dehydrogenase X EC 1.1.1 EC 1.1.1.112,3-alpha-HSD type II, brain EC 1.1.1.188 EC 1.1.1.213 EC 1.1.1.63 EC 1.1.1.64 EC 1.3.1.20 HA1753 HAKRBtype IIb 3-alpha hydroxysteroid dehydrogenase HAKRe HSD17B5 hydroxysteroid (17-beta) dehydrogenase 5 Indanol dehydrogenase KIAA0119hluPGFS PGFS Prostaglandin F synthase Testosterone 17-beta-dehydrogenase 5 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Research Areas for Aldo-keto Reductase 1C3/AKR1C3

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Lipid and Metabolism