5-HT6 Products

Description

5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. 5-HT6 Receptor has been reported primarily in striatum of the brain. Expression has also been seen in stomach, spinal cord, and the lymphoid tissues of rats, including peripheral blood lymphocytes, spleen, and thymus. ESTs have been isolated from brain libraries.

Bioinformatics

Entrez	15565 Mouse 3362 Human 64354 Rat
Uniprot	NM_000871 Human P50406 Human Q9R1C8 Mouse
Product By Gene ID	3362
Alternate Names	5-hydroxytryptamine (serotonin) receptor 6,5-HT65-HT6R Serotonin receptor 6,5-HT-6,5-hydroxytryptamine receptor 6

Research Areas for 5-HT6

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission