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Staufen1 Overabundance and the Consequent mTOR Hyperactivity in Amyotrophic Lateral Sclerosis, Spinocerebellar Ataxia Type 2, Alzheimer’s, Parkinson’s, and Huntington’s Diseases

3D rendering of neurons as a banner image.

Jamshed Arslan, Pharm D, PhD

Tags: 
Amyotrophic Lateral Sclerosis
ALS
Spinocerebellar Ataxia Type 2
Alzheimer’s
Parkinson’s
Huntington’s
neurodegeneration
Autophagy
Neurons
Staufen
TOR/mTOR
Jamshed Arslan

HIV-associated neurocognitive disorders involve extracellular Nef-induced modification of lipid rafts and redistribution of Alzheimer’s disease-related proteins

Immunohistochemical staining of paraffin-embedded ovarian cancer tissue sample with lipid-related protein Apolipoprotein E/ApoE.

Jamshed Arslan, Pharm D, PhD

Tags: 
Alzheimer’s
Cholesterol
HIV
Human Immunodeficiency Virus
HAND
Lipid Raft
neurodegeneration
Neurons
Parkinson’s
ABCA1
Acetylcholinesterase/ACHE
alpha Synuclein
APP
Beta Amyloid 42
Tau
Jamshed Arslan

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

Tags: 
HIV
Human Immunodeficiency Virus
Mitochondria
Mitophagy
ROS
Oxidative Stress
GP120
Tat
Methamphetamine
neurodegeneration
Neurons
LC3B
p62
Autophagy
MAP2
DRP1
Antioxidants
Jamshed Arslan

Mechanisms of Neurodegeneration: Neuroinflammation and microglial activation

Alzheimer's Disease and Neuroinflammation Poster, R&D Systems, showing blood vessle and both health and diseased neurons.

By Michalina Hanzel, PhD

Tags: 
Alzheimer’s
Parkinson’s
Huntington’s
Neuroinflammation
Microglia
beta amyloid
trem-2
siglec-3-cd33
Michalina Hanzel

Mechanisms of Neurodegeneration: Mitochondrial Dysfunction and Oxidative Stress

3D image of dopaminergic neurons shown in green, Bio-Techne.

By Michalina Hanzel, PhD

Tags: 
Alzheimer’s
Parkinson’s
Huntington’s
Autophagy
Alpha-Synuclein
ndufa1
Dopamine
Dopamine D1 R/DRD1
Oxidative Stress
Reactive Oxygen Species
Michalina Hanzel

Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy

Alzheimer’s disease video Novus Biologicals

By Michalina Hanzel, PhD

Tags: 
Alzheimer’s
Parkinson’s
Huntington’s
beta-amyloid
Presenilin-1
macroautophagy
Autophagy
ATG9A
mTOR
Huntingtin
Alpha-Synuclein
beclin-1
APP
Michalina Hanzel

How a cell "reaches" out for help

Expression of alpha-synuclein in rat neuron-glial cultures ICCchloroquine-treated, ICC

By Christina Towers, PhD.

Tags: 
Autophagy
autophagosome
Lysosome
LC3
p62/SQSTM1
neurodegeneration
al2/SQSTM1
Parkinson's
F-actin
Lamp-1pha-synuclein
p6

Brain size matters: MTOR regulates autophagy and number of cortical interneurons

MTOR and autophagy

By Jamshed Arslan Pharm.D.

Tags: 
LC3
Beclin
p62
Autophagy
mTOR
Neuronal Marker
Interneuron
GABA
Beclin 1
LC3B
p62/SQSTM1
Ribosomal Protein S6/RPS6m
Neuroscience
neuron
neurodevelopmental
cortical
Jamshed Arslan