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Michalina Hanzel

Astrocytes: Diversity in type and function

In the CNS astrocytes have different functions including modulation of synaptic activity and synaptogenesis, communication with other astrocytes, oligodendrocytes and microglia, as well as modulation of the blood brain barrier.

By Michalina Hanzel, PhD

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Michalina Hanzel

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Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration

Dual expression of ALDH1L1-red and Vimentin-green identifies astrocytes which may be identified by their golden or red fluorescence. ALDH1L1 is expressed in the cell body and processes of astrocytes.

By Michalina Hanzel, PhD

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neurodegeneration

Amyotrophic Lateral Sclerosis

il-1-beta-il-1f2

Michalina Hanzel

Role of GFAP in astrocytes: Lessons from induced pluripotent stem cells in Alexander disease patients

GFAP-green and Neurofilament-red expression in astrocytes of mouse brain cerebellum, IHC

By Michalina Hanzel, PhD

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Alexander disease

Rosenthal fibers

alphab-crystallin-cryab

Michalina Hanzel

Mechanisms of Neurodegeneration: Neuroinflammation and microglial activation

Alzheimer's Disease and Neuroinflammation Poster, R&D Systems, showing blood vessle and both health and diseased neurons.

By Michalina Hanzel, PhD

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Neuroinflammation

Michalina Hanzel

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Mechanisms of Neurodegeneration: Mitochondrial Dysfunction and Oxidative Stress

3D image of dopaminergic neurons shown in green, Bio-Techne.

By Michalina Hanzel, PhD

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Alpha-Synuclein

Dopamine D1 R/DRD1

Oxidative Stress

Reactive Oxygen Species

Michalina Hanzel

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Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy

Alzheimer’s disease video Novus Biologicals

By Michalina Hanzel, PhD

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Alpha-Synuclein

Michalina Hanzel

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The role of Wnts in neuroinflammation

By Michalina Hanzel, PhD

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neurodegeneration

non-canonical WNT

Michalina Hanzel

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