Antibody News

Profilin-1, or Pfn-1, is a small actin-binding protein which plays an essential role controlling the growth of microfilaments. Profilin 1 and Profilin 2 have similar biochemical properties but are expressed in different tissues. The Profilin 1 antibody targets the more common form of the protein, which is expressed everywhere but the skeletal muscle. We at Novus Biologicals have an extensive range of Profilin I and Profilin II antibody products in our antibody catalog.

Profilin regulates the spatial and temporal growth of actin microfilaments, thus aiding cellular migration, changes in cellular morphology, and processes such as organ development and wound healing to take place. Profilin mainly binds to actin, but has over 50 binding partners in total. Profilin I antibody studies have shown that the protein may have other functions apart from actin regulation.

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Tumor necrosis factor alpha, or TNF alpha antibody products are widely used in cytokine and immunology research. TNF alpha is a pleiotropic ligand which plays an essential role in apoptosis, immune system development and the inflammatory response. We at Novus Biologicals have a number of TNF alpha antibody products in our catalog, which was recently enhanced by the addition of a new neutralizing TNF alpha antibody (NBP1-43235) . It is reactive against mouse, rat and rabbit tumour TNF-a, but not the human form of the antigen.

In nature, neutralizing antibodies defend cells from attack by antigens by neutralizing their biological effects. Normally, antibody binding flags antigens, which signal for their destruction – a response which may be...

We at Novus Biologicals are one of the leading antibody suppliers for cancer research. In a recent Notch antibody study, the Notch ligand Jagged 2 was found to promote the growth of metastatic lung cancer cells by inhibiting miR-200, which blocks epithelial-to-mesenchymal transition (EMT) – an early stage in metastasis which, if blocked, can prevent secondary tumour growth.

The Notch proteins are large single-pass transmembrane receptors, important to embryonic development cell signalling. It comprises an intracellular and extracellular domain, the latter being composed of EGF-like repeats and cysteine-rich Notch/Lin-12 repeats. Notch signalling is initiated following Delta or Jagged1/2 ligand binding. Antibody studies have shown this results in cleavage of the extracellular domain, initiating translocation of the intracellular fragment to the nucleus, triggering transcription...

Adiponectin (also called ADIPOQ) is a cytokine expressed exclusively in adipose tissue. It has a number of functions, regulating lipid metabolism, gluconeogenesis and the inflammatory response. Adiponectin antibody products are widely used in diabetes, obesity and lipid metabolism research. Obesity and Type 2 Diabetes are linked to an increased risk of breast cancer in women. New adiponectin antibodies recently proved important in this area of research.

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The V5 tag antibody identifies the V5 epitope tag, enabling proteins of interest to be analyzed and studied via ELISA, Western blot and other immunochemical methods. We at Novus Biologicals are one of the leading suppliers of epitope tag reagents, with an extensive range of V5 tag antibody products on our antibody database.

An epitope tag is a short peptide sequence, which is bioengineered onto the N- or C- terminus of a protein so it can be recognized by the equivalent antibody, or antibody paratope (i.e. the area of the immunoglobulin receptive to that tag).

Epitope tags are created using recombinant DNA technology, which allows the fusion of a short sequence of...

Novus is launching a new Travel Grant offer for researchers who provide feedback on our antibodies.

For each complete product review that you submit, you will be entered into a drawing for a $500 travel grant! We will select a winner every 3 months - giving you 4 chances for you to win each year!  The winner will receive a $200 airline voucher and $300 towards registration for a scientific conference of your choice.

Complete reviews will require a descriptive summary of the experiment and results, regardless of whether they are positive or negative, and a high quality image. However, researchers may also submit reviews for previously untested species and applications that are being tested under the Innovators Reward Program. Therefore, you could earn Innovators Rewards, Novus points toward a future discount, and be entered to win the Travel Voucher, all by submitting one review...

Sorting Nexin Family Member 27 (SNX27) binds the cell membrane to regulate endocytic vesicular and protein trafficking. SNX27 has also been shown to play a key role in the endocytic recycling pathway, whereby internalized membrane proteins and lipids are degraded and recycled into the cell, in T lymphocytes. In their groundbreaking work on endocytic recycling pathways, Dr. F Maxfield and Dr. T McGraw showed that these pathways are essential for proper organelle maintenance and homeostatic regulation of molecules.

Although it contains the characteristic internal endosome binding PZ domain,...

COX IV isoform 1 is a nuclear-encoded polypeptide chain of the Cytochrome C Oxidase enzyme, located on the mitochondrial inner membrane. Owing to its widespread distribution in human and mammalian tissues, COX IV antibodies are widely used as loading controls for immunological assays. However, following pioneering research done by Wang et al in 1996, the COX IV antibody catalog has also proven useful in the areas of hypoxia, apoptosis and cancer research.

Cytochrome c oxidase is the terminal enzyme of the electron transport chain in the mitochondria. Its function is to couple electrons transferred from reduced cytochrome C to molecular oxygen, contributing to a proton electrochemical gradient in the process. The COX complex in composed of 13 mitochondrial-encoded and nuclear-encoded...

The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.

Human caspases form three distinct groups: cytokine activators, which are involved with cytokine processing and the inflammatory response, and apoptosis initiators and activators (also called executioners). Caspase 3, 6 and 7 are executioners, while caspases 2, 8, 9 and 10 are all initiators.

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What is CD11b?

CD11b is an integrin family member which pairs with CD18 to form the CR3 heterodimer. CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen cells and 44% of bone marrow cells. Functionally, CD11b regulates leukocyte adhesion and migration to mediate the inflammatory response. CD11b antibody studies have shown the protein to be directly involved in cellular adhesion, although migration can only take place in the presence of the CD18 subunit. As well as playing a role in various adhesion reactions, CD11b is a receptor for complement C3bi, mediating complement-coated particle uptake. Research using CD11b antibodies has identified CD11b as a receptor for fibrinogen gamma chain, factor X and ...

Adiponectin is an adipocytokine protein that positively regulates metabolism of lipids and glucose by suppressing glucose production from the liver, stimulating insulin sensitivity, and increasing the rate of fatty acid oxidation and glucose uptake. Insulin resistance, obesity and dyslipidemia (abnormal blood lipid levels) are all linked to Adiponectin deficiency. The Adiponectin antibody is also used in Type 2 Diabetes research.

In recent years, a number of antibody studies have focused on the metabolic pathways governing Adiponectin. In 2003, Yamauchi, et al. identified two Adiponectin receptors, Adipo R1 and Adipo R2. Subsequent experiments showed Adipo R1 to be the primary receptor in skeletal muscle, which is the body's main glucose-utilizing tissue. However, the underlying mechanism of...