Sorting Nexin Family Member 27 (SNX27) binds the cell membrane to regulate endocytic vesicular and protein trafficking. SNX27 has also been shown to play a key role in the endocytic recycling pathway, whereby internalized membrane proteins and lipids are degraded and recycled into the cell, in T lymphocytes. In their groundbreaking work on endocytic recycling pathways, Dr. F Maxfield and Dr. T McGraw showed that these pathways are essential for proper organelle maintenance and homeostatic regulation of molecules.
Although it contains the characteristic internal endosome binding PZ domain, SNX27 is unique among the sorting nexin proteins because it is the only one with a functional PDZ domain. Specifically, the N-terminal PDZ domain interacts with Kir3, DGKZ, PSCDBP and HT4R.
SNX27 antibodies have proven useful tools for understanding the complex signal transduction pathway regulating endocytosis. Novus now offers top quality SNX27 antibodies in a variety of fluorescent conjugated formats. Please contact our technical support department (technical@novusbio.com) with any inquiries or for help selecting the best antibody for your experiment.
