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RCC1

Transportin 1 and heterogeneous nuclear ribonucleoprotein D (hnRNPD)

Transportin 1, also known as Karyopherin- β 2 or Importin- β 2, is part of the β-karyopherins family, which consists of importins and exportins responsible for the active transport of proteins between the nucleus and cytoplasm.  Transportin 1 is composed of twenty HEAT (or a tandem repeat protein structural motif comprised of two alpha helices that end with a short loop) stacks that form a helix.  In the presence of Ran-GTP, Transportin 1 undergoes a conformational change to release the cargo it’s transporting.  Transportin 1 is known to bi