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p38

Liver ASK1 activates autophagy to protect against hepatic fat accumulation, non-alcoholic steatohepatitis and fibrosis

MAPK Signaling Links Autophagy and Inflammation

TGF-beta for treating degenerative intervertebral disc disease

TGF-beta poster

By Jamshed Arslan Pharm.D.

CD95 Mediates Neurovascular Development

MAPK3/ERK1 - A signal transduction pathway with roles in development and disease

Mitogen-activated protein kinases (MAPKs) are important signaling proteins needed to transmit and relay extracellular stimuli and to illicit intracellular responses (1). The MAPK family of proteins are serine/threonine kinases that are able to phosphorylate and activate downstream kinases in a signal cascade that regulates diverse cell responses such as gene expression, metabolism, apoptosis, and differentiation (1). Notable members of the MAPK family include ERK, JNK, and p38 (1).