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PKR-like ER kinase

IRE1 alpha (inositol-requiring enzyme 1 alpha)

The unfolded protein response (UPR) is a eukaryotic cell process that addresses ER stress. UPR is initiated by three ER-localized sensors: PKR-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 alpha (IRE1 alpha). UPR-downstream signaling is modulated by the ATF6 and IRE1-XBP1 pathways.

IRE1 alpha - stress no more!

The unfolded protein response (UPR) is a eukaryotic cell mechanism that copes with ER stress and is initiated by three ER-localized sensors: PKR-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 alpha (IRE1 alpha). The UPR-responsive downstream signaling is regulated through the ATF6 and IRE1-XBP1 pathways.