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Neurodegeneration

Successful Transplantation of Friedreich Ataxia Induced Pluripotent Stem Cell (iPSC)-Derived Sensory Neurons in Dorsal Root Ganglia of Adult Rodents

Jamshed Arslan, Pharm D, PhD

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Staufen1 Overabundance and the Consequent mTOR Hyperactivity in Amyotrophic Lateral Sclerosis, Spinocerebellar Ataxia Type 2, Alzheimer’s, Parkinson’s, and Huntington’s Diseases

Jamshed Arslan, Pharm D, PhD

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Amyotrophic Lateral Sclerosis

Spinocerebellar Ataxia Type 2

neurodegeneration

HIV-associated neurocognitive disorders involve extracellular Nef-induced modification of lipid rafts and redistribution of Alzheimer’s disease-related proteins

Jamshed Arslan, Pharm D, PhD

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Human Immunodeficiency Virus

neurodegeneration

Acetylcholinesterase/ACHE

alpha Synuclein

Beta Amyloid 42

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress

Immunocytochemical staining of formalin-fixed, permeabilized PC12 cells with rabbit polyclonal DRP1 antibody and detected with Dylight 488 (green) and the nuclei counterstained with DAPI (blue).

By Jamshed Arslan, Pharm. D., PhD.

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Human Immunodeficiency Virus

Oxidative Stress

Methamphetamine

neurodegeneration

Increased wild type FUS levels in ALS patients lead to a toxic microenvironment and motor neuron neurodegeneration

Dual expression of ALDH1L1-red and Vimentin-green identifies astrocytes which may be identified by their golden or red fluorescence. ALDH1L1 is expressed in the cell body and processes of astrocytes.

By Michalina Hanzel, PhD

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neurodegeneration

Amyotrophic Lateral Sclerosis

il-1-beta-il-1f2

Michalina Hanzel

Mechanisms of Neurodegeneration: Neuroinflammation and microglial activation

Alzheimer's Disease and Neuroinflammation Poster, R&D Systems, showing blood vessle and both health and diseased neurons.

By Michalina Hanzel, PhD

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Neuroinflammation

Michalina Hanzel

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Mechanisms of Neurodegeneration: Mitochondrial Dysfunction and Oxidative Stress

3D image of dopaminergic neurons shown in green, Bio-Techne.

By Michalina Hanzel, PhD

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Alpha-Synuclein

Dopamine D1 R/DRD1

Oxidative Stress

Reactive Oxygen Species

Michalina Hanzel

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Mechanisms of Neurodegeneration: Protein aggregation and failure of autophagy

Alzheimer’s disease video Novus Biologicals

By Michalina Hanzel, PhD

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Alpha-Synuclein

Michalina Hanzel

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Animal Models to Study Autophagy

By Christina Towers, PhD

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Christina Towers

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Phagocytes in Multiple Sclerosis: Myelin uptake leads to oxysterol-induced activation of liver X receptors, LXRs

By Jamshed Arslan Pharm.D., PhD.

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Multiple Sclerosis

neurodegeneration

Myelin basic protein

Apolipoprotein E

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