Caspase 3 is a member of the cysteine-aspartic acid protease family and an important mediator of apoptosis. Caspase 3 antibody reagents have been used in cancer, Alzheimer's disease and stem cell research. A recent caspase 3 antibody ELISA study showed elevated levels of the p17 caspase 3 fragment were associated with myocardial infarction in humans. We at Novus Biologicals are one of the leading antibody suppliers of caspase products.
Caspase 3 is one of the effector group of caspases, initiating DNA fragmentation and chromatin condensation in apoptosis, via substrate cleavage following activation by either death ligand or mitochondrial action. It interacts with the initiators, Caspase 8 and Caspase 9, and plays a predominant role in the cleavage of amyloid-beta 4A, which has been linked to neuronal cell death in Alzheimer's patients. As well as its role in apoptosis, caspase 3 is now known to be important to normal brain cell development, and may be involved in the differentiation of embryonic stem cells and hematopoietic stem cells.
-Immunohistochemistry-Paraffin-NB500-210-img0001.jpg "Immunohistochemistry-Paraffin: Caspase 3 Antibody")
Research into acute Myocardial Infarction (AMI), has shown apoptosis of cardiac monocytes to follow development of infarcts in animal models. However, results have been uncertain in human patients. In January 2011, Mariela Agosto, et al. published a paper showing serum caspase 3 p17 fragments were elevated in patients with ST-segment elevation Myocardial Infarction (STEMI). STEMI has a high mortality risk, which can be reduced by reperfusion of the myocardium. However, injury can occur, which in animals leads to apoptosis – the end effector of which is p17 caspase 3.
Using p17 caspase 3 antibody ELISA techniques, Agosto was able to show a four-fold increase of p17 caspase 3 levels in patients undergoing treatment for STEMI, compared to healthy controls.
Novus Biologicals offers many Caspase 3 reagents for your research needs including:
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