TERT Products

Description

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes. Telomeres regulate several crucial cellular functions and participate in the control of complex phenotypes, such as aging and cancer. Cell immortalization is strongly associated with the stabilization of telomere length. Therefore, it is suggested that cancer cells achieve immortalization in part through illegitimate activation of telomerase expression. Telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of telomerase. Telomerase is a ribonucleoprotein composed of an internal telomerase RNA template (TERC) and the enzyme TERT. Telomerase is an enzyme uniquely associated with immortal cell lines and is useful for identifying undifferentiated PSCs.

Bioinformatics

Entrez	21752 Mouse 301965 Rat 7015 Human
Uniprot	NP_937983 Human O14746 Human
Product By Gene ID	7015
Alternate Names	EST2Telomerase-associated protein 2 hEST2 hTERT TCS1EC 2.7.7.49 Telomerase catalytic subunit telomerase reverse transcriptase TP2HEST2 TRTEC 2.7.7

Research Areas for TERT

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cellular Markers
Chromatin Research
DNA Repair
DNA replication, Transcription, Translation and Splicing
Embryonic Stem Cell Markers
Phospho-Specific
Stem Cell Markers

Related TERT Blog Posts

Check out the latest blog posts on TERT.

Featured Product Citation using Novus' hTERT Antibody In December 2009, researchers at the University of Southern California cited using Novus’ mouse monoclonal Telomerase Reverse Transcriptase Antibody (cat# NB100-317) [PMID: 19923445]. Specifically, Novus’ hTERT antibody was used for immunofluorescent ...    Read more.

Reversing Cancer with Telomerase Reverse Transcriptase (TERT) Telomerase reverse transcriptase (TERT) is a ribonucleoprotein enzyme essential for eukaryotic chromosomal termini replication. It is a useful marker as it is active only in progenitor and most cancer cells, but inactive or (active at very low activit...    Read more.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease  By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.

Read more TERT related blogs.