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Epigenetic ModulatorsUncovering underlying epigenetic mechanisms controlling gene expression is facilitated by the use of modulators, inhibitors or activators of epigenetic enzymes. A variety of small molecule modulators selectively target DNA methyltransferases and histone modifying enzymes (HMT, HDM, HAT, HDAC). Chemical epigenetic modulators serve as useful probes to dissect the role of specific modifying enzymes in the process of transcriptional regulation.
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