Recombinant Mouse Ephrin-A4 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin-A4, also known as LERK-4 and EFL-4 (1), is a member of the ephrin ligand family which binds members of the Eph receptor family. All ligands share a conserved extracellular sequence, which most likely corresponds to the receptor binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The A-class ligands have a GPI anchor following the conserved sequence. Ephrin-A4 has been shown to bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1 (2, 3). The extracellular domains of human and mouse Ephrin-A4 share 80% amino acid identity. Only membrane-bound or Fc-clustered ligands are capable of activating the receptor in vitro. While soluble monomeric ligands bind the receptor, they do not induce receptor autophosphorylation and activation (2). In vivo, the ligands and receptors display reciprocal expression (3). It has been found that nearly all receptors and ligands are expressed in developing and adult neural tissue (3). The Eph/ephrin families also appear to play a role in angiogenesis (3).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, IHC-Fr.

Showing Publications 1 - 2 of 2.

Publications using 569-A4	Applications	Species
Stiffel V, Amoui M, Sheng M, Mohan S, Lau K EphA4 receptor is a novel negative regulator of osteoclast activity. J Bone Miner Res, 2014-04-01;29(4):804-19. 2014-04-01 [PMID: 23983218] (Bioassay, Mouse)	Bioassay	Mouse
Mason HA, Rakowiecki SM, Raftopoulou M, Nery S, Huang Y, Gridley T, Fishell G Notch signaling coordinates the patterning of striatal compartments. Development, 2005-08-24;132(19):4247-58. 2005-08-24 [PMID: 16120638] (IHC-Fr, Mouse)	IHC-Fr	Mouse

Array 569-A4

• Ephrin-A4 Antibodies
• Ephrin-A4 ELISA Kit
• Ephrin-A4 Lysates
• Ephrin-A4 Proteins and Enzymes