Recombinant Human MUC-1 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

MUC-1 (Mucin-1) is a type 1 transmembrane glycoprotein that is normally expressed on the apical surface of most epithelial cells (1-2). It is known to be overexpressed by various human carcinomas and is shed into circulation (2). The extracellular domain is made up of tandem repeats (TRs) of 20 aa each, with each TR containing five potential O-glycosylation sites (3). The number of TRs vary between 25-100, depending on the allele (3). Within the mature region including 16 TRs (residues 24-380), human MUC-1 shares 30% aa sequence identity with mouse and rat MUC-1. It has been reported that high expression level of MUC-1 generally correlates with increased mortality rates (4). In addition, MUC-1 is aberrantly underglycosylated on cancer cells with short and sialylated O-linked glycans in contrast to the long, branched chain seen in normal epithelial cells (4-7). It has been demonstrated that MUC-1 can interact with E-selectin and ICAM-1 to mediate firm adhesion of circulating tumor cells and subsequent extravasation in the metastatic adhesion cascade (4). Furthermore, MUC-1 can modulate the tumor immunological microenvironment through engagement of Siglec-9 by inducing the recruitment of beta-catenin to the cytoplasmic tail of MUC-1, increasing the expression of PD-L1 by macrophages, and activating the MEK-ERK pathway (5,6). MUC-1 can also interact with Galectin-3 to promote EGFR activation thus regulating EGFR-associated tumorigenesis and cancer progression (7).

We have publications tested in 2 confirmed species: Human, Xenograft.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 2 of 2.

Publications using 10332-MU	Applications	Species
Kawano, T;Englisch, C;Hisada, Y;Paul, D;Archibald, S;Grover, S;Pabinger, I;Ay, C;Mackman, N; Mucin 1 and venous thrombosis in tumor-bearing mice and patients with cancer Thrombosis research 2024-03-21 [PMID: 38547690] (Bioassay, Xenograft)	Bioassay	Xenograft
K Pedram, NN Laqtom, DJ Shon, A Di Spiezio, NM Riley, P Saftig, M Abu-Remail, CR Bertozzi Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals Proceedings of the National Academy of Sciences of the United States of America, 2022-09-19;119(39):e2117105119. 2022-09-19 [PMID: 36122205] (Bioassay, Human)	Bioassay	Human

Array 10332-MU

• MUC1 Antibodies
• MUC1 Antibody Pair
• MUC1 ELISA Kits
• MUC1 Lysates
• MUC1 Proteins
• MUC1 Proteins and Enzymes