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Recombinant Human LRRN2 His-tag, CF

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2 μg/lane of Recombinant Human LRRN2 His-tag was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 73-81 kDa.
2 μg/lane of Recombinant Human LRRN2 His-tag was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 73-81 kDa.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human LRRN2 His-tag, CF Summary

Details of Functionality
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Human LRRN2, immobilized at 2.5 μg/mL on a 96 well plate, is able to significantly enhance neurite outgrowth.
Source
Chinese Hamster Ovary cell line, CHO-derived human LRRN2 protein
Ala19-Gly630, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Ala19 & Val20
Protein/Peptide Type
Recombinant Proteins
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
69 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
73-81 kDa, under reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 500 μg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human LRRN2 His-tag, CF

  • FIGLER7
  • GAC1
  • GAC1LRRN5
  • Glioma amplified on chromosome 1 protein
  • immunoglobulin and leucine rich repeat domain 7
  • leucine rich and ankyrin repeats 1
  • leucine rich repeat neuronal 2
  • leucine rich repeat neuronal 5
  • leucine-rich repeat neuronal protein 2
  • Leucine-rich repeat neuronal protein 5
  • LRANK1
  • LRRN2
  • LRRN5

Background

Leucine-rich repeat neuronal protein 2 (LRRN2) is a type I transmembrane protein containing leucine-rich repeats (1). Mature human LRRN-2 consists of a 612 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 62 aa cytoplasmic domain. Within the ECD, human LRRN-2 shares 92% with mouse and rat LRRN-2. LRRN-2 is expressed in neuronal tissue postsynaptic membranes (1, 2). It is involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. LRRN-2 regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites (1, 2). LRRN-2 is up-regulated after NGF-induced differentiation and down-regulated after NGF depletion-induced apoptosis in mouse superior cervical ganglion cells (2).
  1. Lauren, J. et al. (2003) Genomics 81:411.
  2. Hamano, S. et al. (2004) Int. J. Oncol. 24:1457.

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