Recombinant Human Cbl-B Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cbl-B (Casitas B-lineage lymphoma protooncogene b, aka RNF56) is a member of the Cbl family of RING-type E3 Ubiquitin ligases, and has been implicated in the regulation of pathways associated with cell differentiation, tissue development, skeletal muscle atrophy and adaptive immunity.  Along with its RING-type zinc finger domain, Cbl-B contains an N-terminal tyrosine kinase binding (TKB) domain and a C-terminal UBA (Ubiquitin Associated) domain.  This E3 ligase preferentially interacts with phosphotyrosine-modifed intracellular signaling molecules, targeting them for ubiquitination.  Reported substrates for Cbl-B include VAV1, PIKR1, SYK, SRC, EGFR, AXL and others.  Downregulation of Cbl-B has been shown to remove the requirement for CD28 co-stimulation during T-cell activation, suggesting Cbl-B inhibitors may be useful in various cancer immunotherapies.

Array E3-306

• CBLB Antibodies
• CBLB Lysate
• CBLB Proteins
• CBLB Proteins and Enzyme