p27/Kip1 Antibody

Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using NB100-2816	Applications	Species
Beharry Z, Zemskova M, Mahajan S et al. Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity induce cell cycle arrest in leukemia prostate cancer cells. Mol Cancer Ther;8(6):1473-1483. 2009-01-01 [PMID: 19509254]
Xia ZB, Popovic R, Chen J et al. The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proc Natl Acad Sci USA 2005-09-01 [PMID: 16169901]
Baldassarre G, Belletti B, Nicoloso MS et al. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 2005-01-01 [PMID: 15652749]

Array NB100-2816

• p27/Kip1 Antibodies
• p27/Kip1 ELISA Kits
• p27/Kip1 Lysate
• p27/Kip1 Proteins
• p27/Kip1 ELISA