Nav1.5 Antibody

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. This antibody is expected to recognise both reported isoforms (NP_000326 and NP_932173).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB600-804	Applications	Species
Olson TM, Michels VV, Ballew JD et al. Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 2005-01-26 [PMID: 15671429]

Array NB600-804

• Nav1.5 Antibodies
• Nav1.5 Proteins