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MRP1 Antibody (464510) [Janelia Fluor® 669]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications CyTOF-ready, Flow
Clone
464510
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 669

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC1929U-100UG
Alexa Fluor 405
IC1929V-100UG
Alexa Fluor 488
IC1929G-100UG
Alexa Fluor 532
FAB1929X
Alexa Fluor 594
IC1929T-100UG
Alexa Fluor 647
IC1929R-100UG
Alexa Fluor 700
IC1929N-100UG
Alexa Fluor 750
IC1929S-100UG
Allophycocyanin
FAB1929A
Biotin
FAB1929B
CoraFluor 1
FAB1929CL1
DyLight 350
FAB1929D
DyLight 405
FAB1929E
DyLight 488
FAB1929K
DyLight 550
FAB1929L
DyLight 594
FAB1929M
DyLight 650
FAB1929W
DyLight 680
FAB1929Y
DyLight 755
FAB1929Z
FITC
FAB1929F
HRP
FAB1929H
Janelia Fluor 525
FAB1929JF525
Janelia Fluor 549
FAB1929I
Janelia Fluor 585
FAB1929JF585
Janelia Fluor 635
FAB1929JF635
Janelia Fluor 646
FAB1929J
PE
FAB1929P
PerCP
FAB1929C
Unconjugated
MAB1929
mFluor Violet 450 SE
FAB1929MFV450
mFluor Violet 500 SE
FAB1929MFV500
mFluor Violet 610 SE
FAB1929MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB1929
Carrier Free
MAB1929
Carrier Free
MAB1929-SP
Carrier Free
IC1929V-100UG
Carrier Free
IC1929U-100UG
Carrier Free
IC1929T-100UG
Carrier Free
IC1929S-100UG
Carrier Free
IC1929R-100UG
Carrier Free
IC1929N-100UG
Carrier Free
IC1929G-100UG
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MRP1 Antibody (464510) [Janelia Fluor® 669] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with human MPR1
Met1-Val1531
Accession # P33527
Specificity
Detects human MRP1. Detects human MRP1-transfected cells, but not irrelevant transfectants by flow cytometry.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
ABCC1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MRP1 Antibody (464510) [Janelia Fluor® 669]

  • ABC29
  • ABCC
  • ABCC1
  • ATP-binding cassette sub-family C member 1
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1
  • EC 3.6.3
  • EC 3.6.3.44
  • GS-X
  • Leukotriene C(4) transporter
  • LTC4 transporter
  • MRP1
  • MRP1DKFZp781G125
  • MRPDKFZp686N04233
  • multidrug resistance associated protein 1
  • multidrug resistance protein
  • multidrug resistance-associated protein 1
  • multiple drug resistance protein 1
  • multiple drug resistance-associated protein

Background

Multidrug Resistance Protein 1 (MRP1) is an integral membrane glycophosphoprotein belonging to the same superfamily of ATP-binding cassette transmembrane transporter proteins as P-glycoprotein. MRP1 is overexpressed in many P-glycoprotein-negative, multidrug resistant cell lines and tumours. It is believed that the main function of MRP in drug resistance is that of a plasma membrane drug efflux pump.

Specifically, MRP1 mediates the export of organic anions and drugs from the cytoplasm. It is through this function, that MRP1 is able to confer resistance to anticancer drugs. MRP1 antibodies are therefore useful tools for cancer testing and research.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for MRP1 Antibody (FAB1929JF669) (0)

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Secondary Antibodies

 

Isotype Controls

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ABC Membrane transporters and the role of MRP1 in drug resistance
ATP-binding cassette (ABC) transporters, alongside ion channels and aquaporins, are ubiquitous membrane-bound proteins that move substrates across extra and intra cellular membranes.  Multidrug resistance-associated protein 1 (MRP1) is a member o...  Read full blog post.
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Bioinformatics

Gene Symbol ABCC1