mGluR1 Antibody [Unconjugated] - C-terminus

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Rat metabotropic glutamate receptor 1 (mGluR1a; also mGlu1a) is a 140 kDa, 1181 amino acid (aa), 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. Group I receptors include mGluR1 and mGluR5. Both are postsynaptic, associated with Gq-like proteins, mobilize Ca++ from intracellular stores, and regulate neuronal excitability by influencing ion channel activity. Their activities are not necessarily redundant. When co-expressed on select neurons, mGluR5 tends to dampen mGluR1 activity. On T cells, mGluR1 is inducible and promotes cell proliferation, while mGluR5 is constitutive and blocks proliferation. mGluR1 has a large glycosylated extracellular domain (ECD) of 574 aa. The ECD either covalently homodimerizes or heterodimerizes with the Ca++-sensor receptor (CaSR). Dimerization creates two subunit-linked “open clamshells” which first bind glutamate, then close, and subsequently undergo rearrangement for signal transduction. There are two alternate splice forms of rat mGluR1. Each shows a short aa substitution and premature truncation after N887 in the cytoplasmic region. The cytoplasmic, C-terminal 310 amino acids of rat mGluR1a are 90% and 97% aa identical to the analogous amino acids in human and mouse mGluR1a, respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array PPS077

• mGluR1 Antibodies
• mGluR1 Lysate
• mGluR1 Proteins