EGLN2/PHD1 Products

Description

HIF prolyl hydroxylase 1 (HPH-3 or EGLN2) is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis.

Bioinformatics

Uniprot	AAH36051 Human NM_053046 Human NM_080732 Human NP_444274.1 Human Q96KS0 Human
Product By Gene ID	112398
Alternate Names	DKFZp434E026 EC 1.14.11 EC 1.14.11.- egl nine homolog 2 (C. elegans) egl nine homolog 2 EIT6 Estrogen-induced tag 6 FLJ95603 HIFPH1 EGL nine (C.elegans) homolog 2 HIF-PH1 HIF-prolyl hydroxylase 1 HPH-1 HPH-3 Hypoxia-inducible factor prolyl hydroxylase 1 PHD1 Prolyl hydroxylase domain-containing protein 1

Research Areas for EGLN2/PHD1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Signal Transduction