hnRNP A2B1 Products

Description

RNA polymerase II transcripts in the nucleus are in complex with several different proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). These proteins act in biological activities such as transcription, pre-mRNA processing, cytoplasmic mRNA ranslation, and turnover.2. hnRNPs can be isolated either by immunoprecipitation or by sucrose gradient fractionation of cell extracts. Isolated hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform.3 The major steadystate proteins of the isolated hnRNP complex are the A1, A2, B1, B2, C1, and C2 with a range of molecular weights (34-43 kDa).3 hnRNP-A2/B1 proteins are located in the nucleus of most tissues cells; however, the hnRNP-A2 protein is found also in the cytoplasm of skin and esophagus cells. In rat brain, hnRNP-A2/B1 proteins are found in neurons in the cerebral cortices, hippocampal formation, olfactory regions, caudate-putamin, and the supraoptic ucleus of the hypothalamus.4 Expression of hnRNP-A2/B1 proteins was found also in lung development and its over expression correlated with lung cancer.5

Bioinformatics

Entrez	3181 Human 362361 Rat 53379 Mouse
Uniprot	AAH00506 Human NP_002128 Human P22626 Human
Product By Gene ID	3181
Alternate Names	DKFZp779B0244 FLJ22720 heterogeneous nuclear ribonucleoprotein A2/B1 heterogeneous nuclear ribonucleoprotein B1 heterogeneous nuclear ribonucleoproteins A2/B1 hnRNP A2 / hnRNP B1 HNRNPA2 HNRNPB1 HNRPA2 HNRPA2B1hnRNP A2/B1 HNRPB1 nuclear ribonucleoprotein particle A2 protein RNPA2 SNRPB1

Research Areas for hnRNP A2B1

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
DNA replication, Transcription, Translation and Splicing