GSK-3 beta Products

Description

Glycogen synthase kinase 3beta (GSK-3 beta) is a Serine/Threonine protein kinas involved in the insulin and wingless pathways (1-2). Originally identified as a regulator of glycogen synthase, it has been shown to regulate a diverse array of cellular functions. GSK-3 beta activity is down regulated by phosphorylation on Serine 9 by PKB, or activated by phosphorylation on Tyrosine 216. Once activated, the protein can phosphorylate p53, c-jun, heat shock factor-1 and cyclin D1 (3-4). It is also known to phosphorylate Tau in Allzheimer's disease. Additionally, increased GSK-3 beta protein levels are found in Alzheimer's disease brains.

Bioinformatics

Entrez	2932 Human 56637 Mouse 84027 Rat
Uniprot	AAA66475.1 Human AAH00251 Human NM_002093 Human NP_001139628.1 Human NP_002084 Human NP_002084.2 Human P49841 Human
Product By Gene ID	2932
Alternate Names	EC 2.7.11 EC 2.7.11.26 glycogen synthase kinase 3 beta glycogen synthase kinase-3 beta GSK-3 beta GSK3beta isoform

Research Areas for GSK-3 beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway

Related GSK-3 beta Blog Posts

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