DRP1 Products

Description

DRP1 is a member of the dynamin GTPase superfamily, which that contributes to mitochondrial division in mammalian cells. DRP1 plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses. Therefore, DRP1 provides a genetic tool to assess the role of mitochondria at synapses.

The DRP1 gene has 3 alternatively spliced transcripts encoding different isoforms, which are alternatively polyadenylated.

Bioinformatics

Entrez	10059 Human 114114 Rat 74006 Mouse
Uniprot	AAH24590 Human AAH24590.1 Human NM_012062 Human NM_012063 Human NP_005681 Human O00429 Human
Product By Gene ID	10059
Alternate Names	DLP1 DRP1Dnm1p/Vps1p-like protein DVLPEC 3.6.5.5 Dymple DYMPLEDYNIV-11 dynamin 1-like Dynamin family member proline-rich carboxyl-terminal domain less dynamin-1-like protein Dynamin-like protein 4 Dynamin-like protein IV Dynamin-like protein Dynamin-related protein 1 FLJ41912 HDYNIV HdynIV VPS1

Research Areas for DRP1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
Mitochondrial Fusion Proteins
Neurodegeneration
Neuroscience
Signal Transduction

Related DRP1 Blog Posts

Check out the latest blog posts on DRP1.

Dynamin-related Protein 1 (DRP1) in Mitochondria and Apoptosis. Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mech...    Read more.

Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease  By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.

Understanding Mitophagy Mechanisms: Canonical PINK1/Parkin, LC3-Dependent Piecemeal, and LC3-Independent Mitochondrial Derived Vesicles By Christina Towers, PhD What is Mitophagy?The selective degradation of mitochondria via double membrane autophagosome vesicles is called mitophagy. Damaged mitochondria can generate harmful amounts of reactive ox...    Read more.

Methamphetamine with HIV induces mitochondrial dysfunction and neuronal injury through oxidative stress By Jamshed Arslan, Pharm. D., PhD. December 1 is the World AIDS Day. Despite the combination antiretroviral therapy, 10-25% of Human Immunodeficiency Virus (HIV)-positive individuals report neurocognitive impairm...    Read more.

Read more DRP1 related blogs.