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Total Colonic Aganglionosis: Disease Bioinformatics

Research of Total Colonic Aganglionosis has been linked to Hirschsprung Disease, Enterocolitis, Intestinal Obstruction, Constipation, Down Syndrome. The study of Total Colonic Aganglionosis has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Total Colonic Aganglionosis include Innervation, Pathogenesis, Defecation, Cell Migration, Dehiscence. These pathways complement our catalog of research reagents for the study of Total Colonic Aganglionosis including antibodies and ELISA kits against RET, EDNRB, EDN3, ACHE, SS18L1.

Top Research Reagents

We have 2360 products for the study of Total Colonic Aganglionosis that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

Enolase 1 Antibody (8G8)

H00002023-M01

Mouse Monoclonal
Species Human, Feline
Applications WB, ELISA, Flow

10 Publications

Enolase 2/Neuron-specific Enolase Antibody

NB110-58870

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

2 Reviews

5 Publications

CCDC6 Antibody

NBP1-85351

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

Tapasin Antibody

NBP1-86968

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication

UCH-L1/PGP9.5 Antibody (31A3)

NB600-1160

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

1 Review

15 Publications

SS18L1 Antibody

NBP2-20486

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

Ret Antibody [Unconjugated]

AF482

Ret was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Mouse Ret Antigen Affinity-purified Polyclonal Antibody (Catalog # AF482) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

$ERBB-family signaling molecules in rat testis cells. (a) Polypeptides in the EGF super-family signal by activating ERBB-family transmembrane receptor tyrosine kinases. ERBB1 is a receptor for ‘classical’ low molecular weight EGF-like peptides. ERBB2 is the primary transducer for ligand-bound ERBB1, ERBB3 and ERBB4. ERBB2’s extracellular domain does not bind known ligands. ERBB3 is a receptor for Neuregulin-1 (NRG1), NRG2 and Neuroglycan-C (CSPG5). Ligand bound ERBB3 displays poor kinase activity and signals most effectively as a heteromer with ERBB1, ERBB2 and/or ERBB4. ERBB4 is a receptor for NRG1, NRG2, NRG3 and NRG4 plus other EGF-like peptides*. (b) Western blotting analysis of ERBB-family proteins in fractions of testis cells from 23-day-old rats. Lysates of type A spermatogonia after proliferating for ~180 days/15 passages in culture (SgL), freshly isolated laminin-binding type A spermatogonia (Sg), laminin non-binding spermatogenic cells (Scy), tubular somatic cells (SC), interstitial somatic cells (IC), MCF7 human mammary gland cells (MCF) and COS7 monkey kidney cells (COS). Arrowheads: ERBBs 1–4 (~185 kDa), RET (~155 and 170 kDa) and TUBA1a (~55 kDa). (c) Relative abundance (qtPCR) of ERBB-family transcripts in testis cells isolated from 23-day-old rats (n=cells from three different rats; ±S.E.M.). Spermatogonia (Sg), Spermatocytes (Scy; differentiating spermatogonia/early spermatocytes), Tubular somatic cells (SC) and Interstitial somatic cells (IC) are cell types described in panel (b). (d) Testis cross-section from 26-day-old tgGCS-EGFP transgenic rats labeled with anti-ERBB2 (Red) overlaying EGFP fluorescence from germ cells (green). Note, cytoplasmic ERBB2 labeling in germ cells resembling differentiating spermatogonia (white arrows) and spermatocytes (yellow arrow). Scale, 40 μm. (e) Rat seminiferous tubule whole mount from 24-day-old wild-type rat labeled using antibodies to ERBB2 (Red) and ZBTB16 (Green). Scale, 20 μm. Note: nuclear ZBTB16 labeling is more robust in ERBB2-dim spermatogonia (cyan arrows), compared with ERBB2-bright spermatogenic cells (white arrows). (f) Rat seminiferous tubule whole mount from a 24-day-old wild-type rat labeled with antibodies to ERBB2 (Red) and phospho-Histone-3 (pH3, Green). Scale, 40 μm. Note: nuclear pH3 in large mitotic ERBB2+ syncytia. Image collected and cropped by CiteAb from the following open publication (https://www.nature.com/articles/cddiscovery201518), licensed under a CC-BY license. Not internally tested by R&D Systems.$