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Infantile Malignant Osteopetrosis: Disease Bioinformatics

Research of Infantile Malignant Osteopetrosis has been linked to Albers-schonberg Disease, Malignant Paraganglionic Neoplasm, Bone Diseases, Anemia, Exanthema. The study of Infantile Malignant Osteopetrosis has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Infantile Malignant Osteopetrosis include Bone Resorption, Osteoclast Differentiation, Tooth Eruption, Osteoclast Development, Bone Remodeling. These pathways complement our catalog of research reagents for the study of Infantile Malignant Osteopetrosis including antibodies and ELISA kits against OSTEOPETROSIS, TNFSF11, TNFRSF11A, TCIRG1, CLCN7.

Top Research Reagents

We have 2054 products for the study of Infantile Malignant Osteopetrosis that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

TRACP/PAP/ACP5 Antibody

H00000054-D01P

Western Blot: ACP5 Antibody [H00000054-D01P] - Analysis of ACP5 expression in human liver.

Western Blot: ACP5 Antibody [H00000054-D01P] - Analysis of ACP5 expression in transfected 293T cell line by ACP5 polyclonal antibody.Lane 1: ACP5 transfected lysate(36.60 KDa).Lane 2: Non-transfected lysate.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

3 Publications

FCER1G Antibody (HL1418) - Azide and BSA Free

NBP3-25463

Immunohistochemistry-Paraffin: FCER1G Antibody (HL1418) - Azide and BSA Free [NBP3-25463] - FCER1G antibody [HL1418] detects FCER1G protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded dog cerebellum. FCER1G stained by FCER1G antibody [HL1418] (NBP3-25463) diluted at 1:100. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Western Blot: FCER1G Antibody (HL1418) - Azide and BSA Free [NBP3-25463] - Whole cell extract (30 ug) was separated by 15% SDS-PAGE, and the membrane was blotted with FCER1G antibody [HL1418] (NBP3-25463) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NFATC1/NFAT2 Antibody

NB100-56732

Western Blot: NFATC1/NFAT2 Antibody [NB100-56732] - Immortalized mouse podocytes. Image from verified customer review.

Immunocytochemistry/Immunofluorescence: NFATC1/NFAT2 Antibody [NB100-56732] - NFAT2 antibody was tested in Raw 246.7 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red). Image objective 40x. An antibody dilution of 1:10 was used.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

2 Reviews

4 Publications

OSTM1 Antibody

NBP1-81829

Western Blot: OSTM1 Antibody [NBP1-81829] - Analysis in control (vector only transfected HEK293T lysate) and OSTM1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Immunohistochemistry-Paraffin: OSTM1 Antibody [NBP1-81829] - Staining of human liver shows strong granular cytoplasmic positivity in hepatocytes.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications

DAP12 Antibody

NBP1-85313

Immunohistochemistry-Paraffin: DAP12 Antibody [NBP1-85313] - Analysis in human bone marrow and skeletal muscle tissues using NBP1-85313 antibody. Corresponding TYROBP RNA-seq data are presented for the same tissues.

Western Blot: DAP12 Antibody [NBP1-85313] - Analysis in control (vector only transfected HEK293T lysate) and TYROBP over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication

TDRD7 Antibody

NBP1-87315

Immunohistochemistry: TDRD7 Antibody [NBP1-87315] - Staining of human testis shows cytoplasmic and nuclear positivity in subsets of testicular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication

CLCN7 Antibody

NBP1-91791

Immunocytochemistry/Immunofluorescence: CLCN7 Antibody [NBP1-91791] - Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.

Immunohistochemistry-Paraffin: CLCN7 Antibody [NBP1-91791] - Staining of human duodenum shows strong granular cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

Carbonic Anhydrase II/CA2 Antibody

NB600-919

Western Blot: Carbonic Anhydrase II/CA2 Antibody [NB600-919] - Differential expression of CAIX and CAXII in patient-derived tumor grafts. Frozen tissue samples from PDX tumors were homogenized in RIPA buffer containing protease inhibitor. Western blots were probed with antibodies for CAIX, CAXII, CAII, ER, E-cadherin, actin, and GAPDH. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0199476) licensed under a CC-BY license.

Immunohistochemistry: Carbonic Anhydrase II/CA2 Antibody [NB600-919] - Staining in nucleus and cytoplasm of proximal and distal tubules, bowman's capsule and glomerular podocytes of human kidney (B) and in basal cells of retina of a mouse eye (C). Formalin fixed/paraffin embedded sections were subjected to heat induced epitope retrieval (HIER) at pH 6.2 and then incubated with rabbit anti-carbonic anhydrase II antibody at 4.0 ug/ml for 60 minutes. The reaction was developed using either MACH 1 universal HRP polymer detection (human kidney) or MACH 4 universal AP polymer detection system (mouse eye) and visualized with 3'3-diamino-benzidine substrate (DAB) or WARP RED.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ELISA, IHC

3 Reviews

11 Publications

TCIRG1 Antibody (6H3)

H00010312-M01

Western Blot: TCIRG1 Antibody (6H3) [H00010312-M01] - Detection against Immunogen (36.74 KDa) .

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, IHC

5 Publications

MITF Antibody

AF5769

MITF was detected in paraffin-embedded sections of human skin using Goat Anti-Human MITF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5769) at 10 &micro;g/mL overnight at 4 &deg;C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Western blot shows lysates of Bowes human melanoma cell line and HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human MITF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5769) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, IHC

9 Publications

Osteocalcin Antibody (190125)

MAB1419

Osteocalcin was detected in immersion fixed MG-63 human osteosarcoma cell line using Mouse Anti-Human/Rat Osteocalcin Monoclonal Antibody (Catalog # MAB1419) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Osteocalcin was detected in human mesenchymal stem cells differentiated into osteocytes using Mouse Anti-Human/Rat Osteocalcin Monoclonal Antibody (Catalog # MAB1419) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights&#8482; 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human, Rat
Applications IHC, CyTOF-ready, ICC

3 Reviews

54 Publications

TRANCE/TNFSF11/RANK L

462-TR/CF

<P align=left>Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TR/CF) induces osteoclast differentiation of the RAW&nbsp;264.7 mouse monocyte/macrophage cell line. The ED<SUB>50</SUB> for this effect is 5-15 ng/mL in the presence of 2.5 μg/mL of a cross-linking antibody, Mouse Anti-polyHistidine Monoclonal Antibody (Catalog&nbsp;# <A class=NoLineLink href=

1&nbsp;μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at&nbsp;36 kDa.

Species Mouse
Applications BA

86 Publications

Osteoprotegerin/TNFRSF11B [Biotin]

DY805

N/A Osteoprotegerin/TNFRSF11B [Biotin]

Species Human
Applications ELISA

86 Publications

TNF-alpha [Unconjugated]

210-TA

Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.

Species Human
Applications BA

3 Reviews

803 Publications

IL-7 [Unconjugated]

207-IL

Recombinant Human IL-7 Protein (Catalog # 207-IL) has a molecular weight (MW) of 16.0 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer.

Species Human
Applications BA

155 Publications

RANK/TNFRSF11A Antibody (9A725) - BSA Free

NB100-56508

Western Blot: RANK/TNFRSF11A Antibody (9A725) [NB100-56508] - Analysis of RANK in transfected 293 cells using RANK antibody at 2 ug/ml.

Flow Cytometry: RANK/TNFRSF11A Antibody (9A725) - BSA Free [NB100-56508] - An intracellular stain was performed on Raw264.7 cells with RANK/TNFRSF11A Antibody (9A725) NB100-56508 (blue) and a matched isotype control MAB002 (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Mouse IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550 (84540, Thermo Fisher).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, IHC

18 Publications

ATP6AP1 Antibody (3A2)

H00000537-M01

Western Blot: ATP6AP1 Antibody (3A2) [H00000537-M01] - Analysis of ATP6AP1 expression in transfected 293T cell line by ATP6AP1 monoclonal antibody (M01), clone 3A2.Lane 1: ATP6AP1 transfected lysate(52 KDa).Lane 2: Non-transfected lysate.

Western Blot: ATP6AP1 Antibody (3A2) [H00000537-M01] - ATP6AP1 monoclonal antibody (M01), clone 3A2 Analysis of ATP6AP1 expression in HeLa.

Mouse Monoclonal
Species Human, Rat
Applications WB, ELISA, S-ELISA

2 Publications

Related Genes

Infantile Malignant Osteopetrosis has been researched against:

Related Pathways

Infantile Malignant Osteopetrosis has been linked to:

Related Diseases

Infantile Malignant Osteopetrosis has been studied in relation to diseases such as:

Related PTMs

Infantile Malignant Osteopetrosis has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Infantile Malignant Osteopetrosis is also known as Autosomal Recessive Lethal Osteopetrosis, Severe Osteopetrosis.

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