Uev1a/UBE2V1 Products

Description

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Bioinformatics

Entrez	7335 Human
Uniprot	AAH00468 Human NM_001032288 Human NP_068823 Human NP_071887.1 Human NP_954595 Human NP_954595.1 Human
Product By Gene ID	7335
Alternate Names	CROC1TRAF6-regulated IKK activator 1 beta Uev1A CROC-1UBE2V ubiquitin-conjugating enzyme E2 variant 1 UEV1A UEV-1CIR1 UEV1DNA-binding protein