UBE2N/Ubc13 Products

Description

UBC13 is a member of the E2 ubiquitin-conjugating enzyme family also known as Ubiquitin-conjugating enzyme E2 N, Ubiquitin-protein ligase N, Ubiquitin carrier protein N and Bendless-like ubiquitin-conjugating enzyme. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. UBC13 forms a heterodimer with UBE2V2 which then catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. UBC13 also mediates transcriptional activation of target genes and plays a role in the control of progress through the cell cycle and differentiation, as well as error-free DNA repair. UBC13 also contributes to the survival of cells after DNA damage.

Bioinformatics

Entrez	116725 Rat 7334 Human 93765 Mouse
Uniprot	AAH03365 Human AAP35519 Human NM_003348 Human NP_003339 Human P61088 Human UBCN_HUMAN Human
Product By Gene ID	7334
Alternate Names	bendless-like ubiquitin conjugating enzyme Bendless-like ubiquitin-conjugating enzyme BLU EC 6.3.2.19 MGC131857 MGC8489 UBC13 Ubc13 UbcH-ben Ubiquitin carrier protein N ubiquitin-conjugating enzyme E2 N ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) Ubiquitin-protein ligase N yeast UBC13 homolog

Research Areas for UBE2N/Ubc13

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Cancer