TRPA1 Products

Description

Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.

Bioinformatics

Entrez	277328 Mouse 312896 Rat 8989 Human
Uniprot	AAI53004.1 Human NP_015628 Human O75762 Human Q6RI86 Rat
Product By Gene ID	8989
Alternate Names	ANKTM1ankyrin-like with transmembrane domains 1 Ankyrin-like with transmembrane domains protein 1 Transformation-sensitive protein p120 transient receptor potential cation channel subfamily A member 1 transient receptor potential cation channel, subfamily A, member 1

Research Areas for TRPA1

Find related products by research area and learn more about each of the different research areas below.

Neuronal Cell Markers
Neuroscience
Neurotransmission
Sensory Systems

Related TRPA1 Blog Posts

Check out the latest blog posts on TRPA1.

Winter is coming, and TRPM8 welcomes the cold! TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...    Read more.

Touch Infographic: From Touch Receptors to the Brain The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for ...    Read more.

TRPA1: A contributor to itching and inflammation? Scratch that! Transient receptor potential A1 (TRPA1) is an ion channel found on the plasma membrane of many cell types that functions in diverse sensory processes such as pain and temperature. The TRPA1 ion channel is specifically expressed in nociceptive neurons,...    Read more.

Read more TRPA1 related blogs.