TRIM Products

Description

TRIM is a 30 kD disulfide-linked protein also known as T cell receptor interacting molecule. TRIM is a type III membrane protein containing a very short extracellular domain (8 amino acids). TRIM is highly expressed in T cells with some expression also observed in NK cells. TRIM is a signaling adaptor molecule that links extracellular and intracellular signaling. The TRIM protein is phosphorylated by Src kinases and associates with the PI3K regulatory subunit alpha after phosphorylation. TRIM has also been shown to associate with TCR alpha, beta, and zeta. The TRIM-4 monoclonal antibody recognizes human TRIM and has been shown to be useful for Western blotting, intracellular staining by flow cytometry, and immunofluorescence staining.

Bioinformatics

Entrez	50852 Human
Uniprot	NP_057472 Human Q6PIZ9 Human
Product By Gene ID	50852
Alternate Names	pp29/30 T cell receptor associated transmembrane adaptor 1 T cell receptor interacting molecule T-cell receptor interacting molecule T-cell receptor-associated transmembrane adapter 1 T-cell receptor-interacting molecule TCRIM TRIMHSPC062

Research Areas for TRIM

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Immunology