TPT1/TCTP Products

Description

Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the central nervous, gastrointestinal, respiratory and immune systems. Histamine release is mediated by the stimulation of mast cells and basophils. Histamine-releasing factor (HRF) is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. HRF belongs to the translationally controlled tumor protein (TCTP) family and is detected as a protein of 21 kDa in mice and 23 kDa in human. It is expressed in several healthy and tumoral cells, including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas and lymphomas, and it is localized in the cytoplasm. HRF plays a pivotal role in allergic diseases, and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down Syndrome.

Bioinformatics

Entrez	116646 Rat 22070 Mouse 7178 Human
Uniprot	AAH22436 Human NM_003295 Human NP_003286 Human NP_003286.1 Human P13693 Human
Product By Gene ID	7178
Alternate Names	FLJ27337 Fortilin Histamine-releasing factor p02 p23 TCTPHRFfortilin translationally-controlled tumor protein tumor protein, translationally-controlled 1

Research Areas for TPT1/TCTP

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Stem Cell Markers