TMPRSS3 Products

Description

Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS3 (also known as ECHOS1) gene, which encodes a transmembrane serine protease, has been found to be responsible for two non-syndromic recessive deafness loci located on human chromosome 21q22.3, DFNB8 and DFNB10.TMPRSS3, a 437 amno acid membrane bound serine protease and a member of the S1 peptidase family. TMPRSS3 contains an amino-terminal signalanchor sequence and a glycosylated extracellular region containing the serine protease domain. Two novel missense mutations of TMPRSS3, W251C and P404L, alter the highly conserved amino acids of the serine protease domain. TMPRSS3 is expressed in many tissues, including fetal cochlea, a subset of pancreatic cancer and various other cancer tissues. TMPRSS3 is also overexpressed in cancer, suggesting that it may be important for processes in metastasis formation and tumor invasion.

Bioinformatics

Entrez	140765 Mouse 64699 Human
Uniprot	NP_076927 Human NP_076927.1 Human NP_115781 Human P57727 Human
Product By Gene ID	64699
Alternate Names	DFNB10 DFNB8 EC 3.4.21 EC 3.4.21.- gene similar to transmembrane serine protease10ECHOS1Serine protease TADG-12 serine protease TADG12 TADG12 transmembrane protease serine 3 transmembrane protease, serine 3 Tumor-associated differentially-expressed gene 12 protein

Research Areas for TMPRSS3

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Cancer