Tec Products

Description

Tec is a member of the Tec family of non-receptor protein-tyrosine kinase (PTK) which also includes Btk, emtk/itk/Tsk, Rlk/Txx and Bmx (1). Tec is composed of a pleckstrin domain (PH), an SH3 and SH2 domain, a catalytic kinase domain and a Tec homology domain (TH) (2). Tec's TH domain interacts with the SH3 domain of Grb2, Src family PTKs (Fyn, Lyn, and Hck), Vav, and c-Kit. Tec is mostly expressed in hematopoietic cells. Tec's SH3 domain interacts with DC28 and has been shown to phosphorylate p62dok, CD28 substrate (3). Tec can phosphorylate Jak kinase in hematopoietic cells (4) and can also be phosphorylated by Src member Lyn on multiple tyrosine residues (5).

Bioinformatics

Entrez	7006 Human
Uniprot	NP_003206 Human P42680 Human TEC_HUMAN Human
Product By Gene ID	7006
Alternate Names	EC 2.7.10 EC 2.7.10.2 MGC126760 MGC126762 PSCTK4tyrosine-protein kinase Tec tec protein tyrosine kinase

Research Areas for Tec

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Protein Kinase