TDP1 Products

Description

TDP1 is encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Bioinformatics

Entrez	55775 Human
Uniprot	AAH15474 Human AAH15474.1 Human NM_018319 Human NP_001008744 Human NP_001008744.1 Human NP_060789 Human Q9NUW8 Human
Product By Gene ID	55775
Alternate Names	EC 3.1.4 EC 3.1.4.- FLJ11090 MGC104252 SCAN1 Tyr-DNA phosphodiesterase 1 tyrosyl-DNA phosphodiesterase 1

Research Areas for TDP1

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Stem Cell Markers