TC10 Products

Description

TC10 is a member of the Rho family of GTP-binding proteins and is closely related to Cdc42 and Rac 1. Cycling between inactive and active GTP-bound state, active TC10 can directly interact with Cdc42 kinase, p21-activated protein kinases as well as other kinases (1). Constitutive expression of active TC10 mutants (TC10/Q75L) in fibroblast decrease actin stress fiber and formation of plasma membrane microspikes, while wild type TC10 has no effect on fibroblast cell morphology (2). Mostly expressed in adipose and muscle tissues, TC10 has been found to be activated by C3G (from the insulin pathway) in adipocytes (3).

Bioinformatics

Entrez	23433 Human
Uniprot	NM_012249 Human NP_036381 Human NP_036381.2 Human P17081 Human
Product By Gene ID	23433
Alternate Names	ARHQTC10A ras homolog gene family, member Q Ras-like protein family member 7A Ras-like protein TC10 RAS-like, family 7, member A rho-related GTP-binding protein RhoQ TC10RASL7A

Research Areas for TC10

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction