Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, Simple Western
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Description
Sprouty 2 encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10253 |
| Alternate Names |
- hSPRY2
- MGC23039
- protein sprouty homolog 2
- sprouty (Drosophila) homolog 2
- sprouty 2
- sprouty homolog 2 (Drosophila)
- Spry-2
- spry-2
|
![Western Blot SPRY2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SPRY2_AF6157_Western_Blot_9564.jpg)
![Simple Western SPRY2 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/SPRY2_AF6157_Simple_Western_17024.jpg)
