Skp2 Products

Description

The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase 2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F, and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.

Bioinformatics

Entrez	6502 Human
Uniprot	AAH01441 Human NM_005983 Human NP_005974.2 Human Q13309 Human
Product By Gene ID	6502
Alternate Names	CDK2/cyclin A-associated protein p45 cyclin A/CDK2-associated protein p45 Cyclin-A/CDK2-associated protein p45 FBL1 F-box protein Skp2 F-box/LRR-repeat protein 1 FBXL1MGC1366 FLB1 p45skp2 S-phase kinase-associated protein 2 (p45) S-phase kinase-associated protein 2

Research Areas for Skp2

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Cell Cycle and Replication

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