SETDB1 Products

Description

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 039;Enhancer of zeste 039 proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities. [supplied by OMIM]

Bioinformatics

Entrez	9869 Human
Uniprot	CAI13326 Human NM_012432 Human NP_001138887 Human NP_036564 Human Q15047 Human
Product By Gene ID	9869
Alternate Names	ERG-associated protein with SET domain ESETEC 2.1.1.43 H3-K9-HMTase 4 Histone H3-K9 methyltransferase 4 histone-lysine N-methyltransferase SETDB1 histone-lysine N-methyltransferase, H3lysine-9 specific 4 KG1T KIAA0067H3-K9-HMTase4 KMT1EERG-associated protein with a SET domain, ESET Lysine N-methyltransferase 1E SET domain bifurcated 1 SET domain, bifurcated 1

Research Areas for SETDB1

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Epigenetics
Transcription Factors and Regulators